A key step in the hydrolysis of acetamide in | vedclass

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Question

(B) In the acid-catalyzed hydrolysis of acetamide $(CH_3CONH_2)$,the first step is the protonation of the carbonyl oxygen by $H_3O^{+}$ to form a reso

Vedclass · Accepted Answer

$H_2O$ to $CH_3-C(OH^{+})-NH_2$

Vedclass · Answer

(B) In the acid-catalyzed hydrolysis of acetamide $(CH_3CONH_2)$,the first step is the protonation of the carbonyl oxygen by $H_3O^{+}$ to form a resonance-stabilized cation,$CH_3-C(OH^{+})-NH_2$. Following this,the nucleophile,which is water $(H_2O)$,attacks the electrophilic carbonyl carbon of the protonated acetamide. This nucleophilic addition of $H_2O$ to the protonated species $CH_3-C(OH^{+})-NH_2$ is the key step that leads to the formation of the tetrahedral intermediate.

$A$ key step in the hydrolysis of acetamide in aqueous acid proceeds by nucleophilic addition of

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